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A) Body composition analysis by <t>DEXA</t> showing percent of total mass for lean mass and fat mass (lest), total mass of gynoid fat mass (middle) and android fat mass (right). B) Longitudinal measurements of dam weight throughout gestation as a fold change from baseline, C-D) Glucose tolerance test (GTT) performed pre-pregnancy, showing glucose and insulin levels. E-G) Longitudinal measurements of HbA1c, circulating levels of triglycerides and cholesterol throughout gestation. H) Bubble plot of cytokine production throughout gestation in dam plasma measured by Luminex. Bubble size represents the concentration in log10(pg/mL), while bubble color reflects the -log10(qvalue) comparing the timepoint to GD0 for the corresponding group. *p < 0.05 by direct comparison of lean and obese samples at the indicated timepoint.
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A) Body composition analysis by <t>DEXA</t> showing percent of total mass for lean mass and fat mass (lest), total mass of gynoid fat mass (middle) and android fat mass (right). B) Longitudinal measurements of dam weight throughout gestation as a fold change from baseline, C-D) Glucose tolerance test (GTT) performed pre-pregnancy, showing glucose and insulin levels. E-G) Longitudinal measurements of HbA1c, circulating levels of triglycerides and cholesterol throughout gestation. H) Bubble plot of cytokine production throughout gestation in dam plasma measured by Luminex. Bubble size represents the concentration in log10(pg/mL), while bubble color reflects the -log10(qvalue) comparing the timepoint to GD0 for the corresponding group. *p < 0.05 by direct comparison of lean and obese samples at the indicated timepoint.
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A) Body composition analysis by DEXA showing percent of total mass for lean mass and fat mass (lest), total mass of gynoid fat mass (middle) and android fat mass (right). B) Longitudinal measurements of dam weight throughout gestation as a fold change from baseline, C-D) Glucose tolerance test (GTT) performed pre-pregnancy, showing glucose and insulin levels. E-G) Longitudinal measurements of HbA1c, circulating levels of triglycerides and cholesterol throughout gestation. H) Bubble plot of cytokine production throughout gestation in dam plasma measured by Luminex. Bubble size represents the concentration in log10(pg/mL), while bubble color reflects the -log10(qvalue) comparing the timepoint to GD0 for the corresponding group. *p < 0.05 by direct comparison of lean and obese samples at the indicated timepoint.

Journal: bioRxiv

Article Title: Spontaneous Pregravid Obesity Reshapes Fetal Immune Ontogeny in a Nonhuman Primate Model

doi: 10.64898/2026.03.27.714880

Figure Lengend Snippet: A) Body composition analysis by DEXA showing percent of total mass for lean mass and fat mass (lest), total mass of gynoid fat mass (middle) and android fat mass (right). B) Longitudinal measurements of dam weight throughout gestation as a fold change from baseline, C-D) Glucose tolerance test (GTT) performed pre-pregnancy, showing glucose and insulin levels. E-G) Longitudinal measurements of HbA1c, circulating levels of triglycerides and cholesterol throughout gestation. H) Bubble plot of cytokine production throughout gestation in dam plasma measured by Luminex. Bubble size represents the concentration in log10(pg/mL), while bubble color reflects the -log10(qvalue) comparing the timepoint to GD0 for the corresponding group. *p < 0.05 by direct comparison of lean and obese samples at the indicated timepoint.

Article Snippet: For DEXA assessments, monkeys were sedated with ketamine and positioned supine on a Hologic Discovery DEXA scanner (Hologic Inc., Bedford, MA, USA).

Techniques: Clinical Proteomics, Luminex, Concentration Assay, Comparison